Potassium Channel
KcsA
Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.
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Potassium Channel Inhibitors
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Potassium Channel Agonists
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Potassium Channel Antagonists
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Potassium Channel Activators
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Potassium Channel Modulators
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Potassium Channel Chemical
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Potassium Channel Controls
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Potassium Channel Related Products (1122)
Related Products (1122)
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Antibodies (6)
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Related Compound Screening Libraries (1)
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Loureirin B (Standard)
0 ImagesCat. No.: HY-N1504RCAS No.: 119425-90-0Loureirin B (Standard) is the analytical standard of Loureirin B. This product is intended for research and analytical applications. Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC50 of 26.10 μM; Loureirin B also inhibits KATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.
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Quinidine hydrochloride monohydrate (Standard)
0 ImagesQuinidine hydrochloride monohydrate (Standard) is the analytical standard of Quinidine hydrochloride monohydrate (HY-B1302). This product is intended for research and analytical applications. Quinidine hydrochloride monohydrate is an orally active antiarrhythmic agent. Quinidine hydrochloride monohydrate reduces the expression level of P-gp, inhibits P-gp-mediated efflux, increases the intracellular accumulation of P-gp substrates, induces PARP cleavage and Caspase-3 activation, and elevates the proportion of Apoptotic cells at the sub-G1 phase. Quinidine hydrochloride monohydrate exerts sustained block and open-channel block effects on IK(f). Quinidine hydrochloride monohydrate alters the urinary metabolic ratio of Amphetamine, modulates the Pentylenetetrazol-induced seizure threshold, and regulates the anticonvulsant effect of Dextromethorphan. Quinidine hydrochloride monohydrate can be used in studies related to uterine sarcoma and seizures.
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Nerispirdine
0 ImagesCat. No.: HY-106017CAS No.: 119229-65-1Nerispirdine is an ion channel inhibitor with IC50s of 3.6, 3.7 and 11.9 μM against K(v)1.1, K(v)1.2 and voltage-dependent Na(+) channel, respectively. Nerispirdine is a 4-aminopyridine (4-AP, HY-B0604) derivative and can be utilized in research on neurological disorders.
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Cibenzoline succinate
0 ImagesCat. No.: HY-115014CAS No.: 100678-32-8Synonyms: Cifenline succinate; Ro 22-7796 succinateCibenzoline succinate (Cifenline succinate) is the succinate form of Cibenzoline (HY-106577). Cibenzoline succinate is an inhibitor for ATP-sensitive potassium (KATP) channel by affecting the pore-forming Kir6.2 subunit with IC50 of 22.2 µM. Cibenzoline succinate affects insulin secretion and exhibits antiarrhythmic and antidiabetic activities.
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SMA-245
0 ImagesCat. No.: HY-187472SMA-245 is an inhibitor of Filovirus glycoproteins, acting on Ebola virus (EBOV) and Marburg virus (MARV). SMA-245 blocks the endosomal membrane fusion step of filoviruses by binding to the EBOV GP1/GP2 fusion loop. SMA-245 inhibits MARV viral entry. SMA-245 can be used in research related to filovirus infections.
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W-7 hydrochloride (Standard)
0 ImagesCat. No.: HY-100912RCAS No.: 61714-27-0W-7 (hydrochloride) (Standard) is the analytical standard of W-7 (hydrochloride) (HY-100912). This product is intended for research and analytical applications. W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 μM and 51 μM, respectively. W-7 hydrochloride induces apoptosis and has antitumor and vascular relaxing activity. W-7 hydrochloride is a blocker of Kv4.3 and can be used for research of arrhythmias.
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GSK369796
0 ImagesCat. No.: HY-12082CAS No.: 459133-38-1GSK369796 is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization with an IC50 of 7.5 μM.
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Hypaconitine (Standard)
0 ImagesHypaconitine (Standard) is the analytical standard of Hypaconitine. This product is intended for research and analytical applications. Hypaconitine inhibits the KCNH2 current with an IC50 of 8.1 nM, and exhibits cardiotoxicity. Hypaconitine inhibits TGF-β1-induced epithelial-mesenchymal transition (EMT) in A549 cell through the inhibition of NF-κB nuclear translocation. Hypaconitine acts as the neuromuscular blocker. Hypaconitine is orally active.
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Doxapram hydrochloride
0 ImagesDoxapram (hydrochloride) is a ventilatory stimulant. Doxapram (hydrochloride) inhibits TASK Tandem Pore (K2P) potassium channel function. Doxapram (hydrochloride) inhibits TASK-1 and TASK-3 with an EC50 values of 410 and 37 nM, respectively. Doxapram (hydrochloride) inhibits TASK-1/TASK-3 heterodimeric channel function with an EC50 value of 9 μM. Doxapram (hydrochloride) can be studied in research on apnea in preterm infants.
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Besipirdine hydrochloride
0 ImagesCat. No.: HY-14607CAS No.: 130953-69-4Synonyms: HP 749Besipirdine (hydrochloride) is a potassium channel blocker with cholinergic and adrenergic activity. The cholinergic activity of Besipirdine (hydrochloride) involves stimulating phosphatidylinositol turnover and reducing potassium currents. The adrenergic activity of Besipirdine (hydrochloride) involves stimulating norepinephrine release, which is attributed to the inhibition of presynaptic α2-adrenergic receptors and the inhibition of norepinephrine uptake. Besipirdine (hydrochloride) may be used in research for Alzheimer's disease.
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LY 303511
0 ImagesCat. No.: HY-15643CAS No.: 154447-38-8LY303511 is a structural analogue of LY294002. LY303511 does not inhibit PI3K. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells. LY303511 reversibly blocks K+ currents (IC50=64.6±9.1 μM) in MIN6 insulinoma cells.
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MSD-D
0 ImagesCat. No.: HY-126936CAS No.: 182504-18-3MSD-D is a potent and frequency-dependent Kv1.5 channel inhibitor with an IC50 value of 0.5 μM. MSD-D is promising for research of atrial-selective class III antiarrhythmics.
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UCL 2077 (Standard)
0 ImagesCat. No.: HY-108592RCAS No.: 918311-87-2UCL 2077 (Standard) is the analytical standard of UCL 2077 (HY-108592). This product is intended for research and analytical applications. UCL 2077 is a selective slow-afterhyperpolarization (sAHP) channel blocker (IC50 = 500 nM in hippocampal neurons in culture), having minimal effects on Ca2+ channels, action potentials, input resistance and the medium after hyperpolarization. UCL 2077 is also a subtype-selective blocker of the epilepsy associated KCNQ channels.
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(rac)-Indapamide-d3
0 ImagesCat. No.: HY-B0259SCAS No.: 1217052-38-4(rac)-Indapamide-d3 is a labelled racemic Indapamide. Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy.
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DMP-543 (Standard)
0 ImagesCat. No.: HY-108590RCAS No.: 160588-45-4Synonyms: XR-543 (Standard)
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Ketanserin (Standard)
0 ImagesSynonyms: R41468 (Standard)Ketanserin (Standard) is the analytical standard of Ketanserin. This product is intended for research and analytical applications. Ketanserin is a selective 5-HT2 receptor antagonist. Ketanserin also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM).
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L-Palmitoylcarnitine-d9
0 ImagesL-Palmitoylcarnitine-d9 is deuterium labeled L-Palmitoylcarnitine. L-Palmitoylcarnitine, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2.
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Amsacrine lactate
0 ImagesCat. No.: HY-13551DCAS No.: 80277-11-8Synonyms: m-AMSA lactate; Acridinyl anisidide lactateAmsacrine lactate (m-AMSA lactate) is a Topoisomerase II inhibitor. Amsacrine lactate intercalates into DNA. Amsacrine lactate induces Ca2+-mediated inactivation of ERK, and also downregulates AKT, promoting MCL1 downregulation mediated by GSK3β via reducing the phosphorylation level of GSK3β. Amsacrine lactate induces Apoptosis by activating Caspase-9 and Caspase-3. Amsacrine lactate blocks HERG potassium channels in the open/inactivated state. Amsacrine lactate induces chromosomal aberrations and sister chromatid exchanges, and inhibits the synthesis of RNA and DNA. Amsacrine lactate exhibits anti-leukemic activity. Amsacrine lactate causes cardiac repolarization disorders, QT interval prolongation, ventricular arrhythmias, and increases the risk of sudden cardiac death. Amsacrine lactate can be used in research related to acute myeloid leukemia, lymphoma and progressive malignancies.
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Quindecamine
0 ImagesCat. No.: HY-Z13814CAS No.: 19056-26-9Quindecamine (UCL 1407) is a potent IKCa blocker with anIC50 of 0.85 μM.
